{
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  "Type": "Package",
  "Title": "Multiomics Data Integration",
  "Version": "0.0.28",
  "Authors@R": "c(person(\"Kai\",\"Guo\",email = \"guokai8@gmail.com\",\nrole = c(\"aut\", \"cre\")\n),\nperson(\"Junguk\",\"Hur\",role = \"aut\"),\nperson(\"Eva\",\"Feldman\",role = \"aut\")\n)",
  "Description": "Provides functions to do 'O2PLS-DA' analysis for multiple\nomics data integration. The algorithm came from \"O2-PLS, a\ntwo-block (X±Y) latent variable regression (LVR) method with an\nintegral OSC filter\" which published by Johan Trygg and Svante\nWold at 2003 <doi:10.1002/cem.775>. 'O2PLS' is a bidirectional\nmultivariate regression method that aims to separate the\ncovariance between two data sets (it was recently extended to\nmultiple data sets) (Löfstedt and Trygg, 2011\n<doi:10.1002/cem.1388>; Löfstedt et al., 2012\n<doi:10.1016/j.aca.2013.06.026>) from the systematic sources of\nvariance being specific for each data set separately.",
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  "URL": "https://github.com/guokai8/o2plsda",
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    "Date": "2026-10-10 12:55:43 UTC",
    "User": "root"
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  "Author": "Kai Guo [aut, cre], Junguk Hur [aut], Eva Feldman [aut]",
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  "_created": "2026-10-10T12:55:43.000Z",
  "_published": "2026-10-10T13:01:53.796Z",
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    "committer": "bioguo <bioguo@0587665262.vpn.umich.net>",
    "message": "revise the code\n",
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    "name": "Kai Guo",
    "email": "guokai8@gmail.com",
    "login": "guokai8",
    "description": "Love coding\nLove cooking",
    "uuid": 9088155
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  "_updates": [
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      "week": "2025-49",
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  ],
  "_tags": [],
  "_topics": [
    "integration",
    "multi-omics",
    "o2pls",
    "omics",
    "plsda",
    "openblas",
    "cpp",
    "openmp"
  ],
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  },
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  "_devurl": "https://github.com/guokai8/o2plsda",
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  "_rbuild": "4.6.1",
  "_assets": [
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    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/o2plsda.html",
    "extra/readme.html",
    "extra/readme.md",
    "LICENSE"
  ],
  "_homeurl": "https://github.com/guokai8/o2plsda",
  "_realowner": "guokai8",
  "_cranurl": true,
  "_releases": [
    {
      "version": "0.0.12",
      "date": "2021-11-19"
    },
    {
      "version": "0.0.14",
      "date": "2022-01-05"
    },
    {
      "version": "0.0.15",
      "date": "2022-03-03"
    },
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      "date": "2025-12-01"
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  ],
  "_exports": [
    "apply_sparsity",
    "AtA",
    "auto_determine_keepX",
    "auto_determine_keepY",
    "calculate_centroid_distances",
    "calculate_classification_error",
    "calculate_mahalanobis_distances",
    "calculate_max_distances",
    "calculate_prediction_probabilities",
    "calculate_regression_error",
    "calculate_sparse_vip",
    "colsds",
    "column_sums",
    "compare_models",
    "create_stratified_folds",
    "cv_sparse_o2pls_single",
    "cv_sparse_plsda",
    "eigenmult",
    "eigenthree",
    "evaluate_sparse_classification",
    "extract_sparse_orthogonal_X",
    "extract_sparse_orthogonal_Y",
    "find_optimal_parameters",
    "find_optimal_sparse_params",
    "fit_sparse_pls",
    "get_sparsity_info_internal",
    "getMCCV_cpp",
    "identify_stable_variables",
    "loadings",
    "loadings.O2pls",
    "loadings.o2plsda",
    "loadings.plsda",
    "o2cv",
    "o2cv_enhanced",
    "o2cv_sparse",
    "o2pls",
    "opls",
    "oplsda",
    "order_cpp",
    "order_str",
    "perform_single_bootstrap",
    "plot_opt_params",
    "plot_s4_biplot",
    "plot_s4_comparison",
    "plot_s4_contribution",
    "plot_s4_diagnostic",
    "plot_s4_loadings",
    "plot_s4_scores",
    "plot_s4_selection",
    "plot_s4_sparsity",
    "plot_sp_classification",
    "plot_sp_loadings",
    "plot_sp_scores",
    "plot_sp_selection",
    "plot_sp_vip",
    "plot_stab_barplot",
    "plot_stab_heatmap",
    "plot_stab_network",
    "plot_stab_summary",
    "plot_stab_threshold",
    "plot_tune_compare",
    "plot_tune_heatmap",
    "plot_tune_line",
    "plot_tune_surface",
    "plot.O2pls",
    "plot.o2plsda",
    "plot.plsda",
    "plot.sparse_plsda",
    "plot.SparseO2pls",
    "plot.stability_selection",
    "plot.TuneResult",
    "plsda",
    "predict",
    "predict_o2pls_classification",
    "predict_o2pls_regression",
    "predict.sparse_plsda",
    "predict.SparseO2pls",
    "preprocess_matrix",
    "print.O2pls",
    "print.plsda",
    "print.sparse_o2pls",
    "print.sparse_plsda",
    "print.SparseO2pls",
    "Q",
    "rcpp_rmse",
    "s2",
    "sample_cpp",
    "sample_lapply",
    "scad_threshold",
    "scores",
    "scores.O2pls",
    "scores.o2plsda",
    "scores.plsda",
    "selected_var_names",
    "selected_var_names.sparse_o2pls",
    "selected_var_names.sparse_plsda",
    "selected_var_names.SparseO2pls",
    "selected_vars",
    "selected_vars.default",
    "selected_vars.sparse_o2pls",
    "selected_vars.sparse_plsda",
    "selected_vars.SparseO2pls",
    "sort_str",
    "sparse_o2pls",
    "sparse_plsda",
    "sparsity_info",
    "sparsity_info.sparse_o2pls",
    "sparsity_info.sparse_plsda",
    "sparsity_info.SparseO2pls",
    "split_str",
    "stability_selection",
    "summary.O2pls",
    "summary.plsda",
    "summary.sparse_o2pls",
    "summary.sparse_plsda",
    "summary.SparseO2pls",
    "tune_sparse_keepX",
    "tune_sparse_o2pls",
    "unlist_cpp",
    "validate_sparse_inputs",
    "validate_tuning_inputs",
    "vip"
  ],
  "_help": [
    {
      "page": "extract-sparse_plsda",
      "title": "Extract elements from sparse_plsda objects",
      "topics": [
        "$,sparse_plsda-method"
      ]
    },
    {
      "page": "extract-SparseO2pls",
      "title": "Extract elements from SparseO2pls objects",
      "topics": [
        "$,SparseO2pls-method"
      ]
    },
    {
      "page": "apply_sparsity",
      "title": "Enhanced sparsity application function (FIXED VERSION)",
      "topics": [
        "apply_sparsity"
      ]
    },
    {
      "page": "calculate_mahalanobis_distances",
      "title": "Calculate Mahalanobis distances for classification",
      "topics": [
        "calculate_mahalanobis_distances"
      ]
    },
    {
      "page": "calculate_prediction_probabilities",
      "title": "Calculate prediction probabilities from distances",
      "topics": [
        "calculate_prediction_probabilities"
      ]
    },
    {
      "page": "compare_models",
      "title": "Compare multiple O2PLS models",
      "topics": [
        "compare_models"
      ]
    },
    {
      "page": "loadings",
      "title": "Extract the loadings from an O2PLS fit",
      "topics": [
        "loadings",
        "loadings.O2pls"
      ]
    },
    {
      "page": "loadings.o2plsda",
      "title": "extract the loading value from the O2PLSDA analysis",
      "topics": [
        "loadings.o2plsda"
      ]
    },
    {
      "page": "loadings.plsda",
      "title": "extract the loading value from the PLSDA analysis",
      "topics": [
        "loadings.plsda"
      ]
    },
    {
      "page": "o2cv",
      "title": "Cross validation for O2PLS",
      "topics": [
        "o2cv"
      ]
    },
    {
      "page": "o2cv_sparse",
      "title": "Enhanced sparse cross-validation that integrates with existing o2cv",
      "topics": [
        "o2cv_sparse"
      ]
    },
    {
      "page": "o2pls",
      "title": "fit O2PLS model with best nc, nx, ny",
      "topics": [
        "o2pls"
      ]
    },
    {
      "page": "O2pls-class",
      "title": "Class \"O2pls\" This class represents the Annotation information",
      "topics": [
        "O2pls-class"
      ]
    },
    {
      "page": "oplsda",
      "title": "Orthogonal partial least squares discriminant analysis",
      "topics": [
        "oplsda"
      ]
    },
    {
      "page": "plot.O2pls",
      "title": "Score or loading plot for the O2PLS results",
      "topics": [
        "plot.O2pls"
      ]
    },
    {
      "page": "plot.o2plsda",
      "title": "Score, VIP or loading plot for the O2PLS results",
      "topics": [
        "plot.o2plsda"
      ]
    },
    {
      "page": "plot.plsda",
      "title": "Score, VIP or loading plot for the plsda results",
      "topics": [
        "plot.plsda"
      ]
    },
    {
      "page": "plot.sparse_plsda",
      "title": "Plot method for Sparse PLS-DA results",
      "topics": [
        "plot.sparse_plsda"
      ]
    },
    {
      "page": "plot.SparseO2pls",
      "title": "Plot method for SparseO2pls S4 objects",
      "topics": [
        "plot.SparseO2pls"
      ]
    },
    {
      "page": "plot.stability_selection",
      "title": "Enhanced plot method for stability_selection objects",
      "topics": [
        "plot.stability_selection"
      ]
    },
    {
      "page": "plot.TuneResult",
      "title": "Enhanced plot method for TuneResult objects",
      "topics": [
        "plot.TuneResult"
      ]
    },
    {
      "page": "plsda",
      "title": "Partial least squares discriminant analysis",
      "topics": [
        "plsda"
      ]
    },
    {
      "page": "predict-sparse_plsda",
      "title": "Predict method for sparse_plsda objects",
      "topics": [
        "predict,sparse_plsda-method"
      ]
    },
    {
      "page": "predict-SparseO2pls",
      "title": "Predict method for SparseO2pls objects",
      "topics": [
        "predict,SparseO2pls-method"
      ]
    },
    {
      "page": "predict.sparse_plsda",
      "title": "Enhanced predict method for sparse PLS-DA",
      "topics": [
        "predict.sparse_plsda"
      ]
    },
    {
      "page": "predict.SparseO2pls",
      "title": "Enhanced predict method for sparse O2PLS",
      "topics": [
        "predict.SparseO2pls"
      ]
    },
    {
      "page": "print.O2pls",
      "title": "Print the summary of O2PLS results.",
      "topics": [
        "print.O2pls"
      ]
    },
    {
      "page": "print.plsda",
      "title": "Print the summary of plsda results.",
      "topics": [
        "print.plsda"
      ]
    },
    {
      "page": "print.SparseO2pls",
      "title": "Print method for sparse O2PLS results",
      "topics": [
        "print.SparseO2pls"
      ]
    },
    {
      "page": "scad_threshold",
      "title": "Enhanced SCAD thresholding function",
      "topics": [
        "scad_threshold"
      ]
    },
    {
      "page": "scores",
      "title": "Extract the scores from an O2PLS fit",
      "topics": [
        "scores"
      ]
    },
    {
      "page": "scores.O2pls",
      "title": "Extract the scores from an O2PLS fit",
      "topics": [
        "scores.O2pls"
      ]
    },
    {
      "page": "scores.o2plsda",
      "title": "Extract the scores from an O2PLS DA analysis",
      "topics": [
        "scores.o2plsda"
      ]
    },
    {
      "page": "scores.plsda",
      "title": "Extract the scores PLSDA analysis",
      "topics": [
        "scores.plsda"
      ]
    },
    {
      "page": "selected_var_names",
      "title": "Get names of selected variables",
      "topics": [
        "selected_var_names"
      ]
    },
    {
      "page": "selected_vars",
      "title": "Extract selected variables from sparse models",
      "topics": [
        "selected_vars"
      ]
    },
    {
      "page": "selected_vars.default",
      "title": "Default method for selected_vars",
      "topics": [
        "selected_vars.default"
      ]
    },
    {
      "page": "selected_vars.sparse_plsda",
      "title": "Extract selected variables from sparse PLS-DA models",
      "topics": [
        "selected_vars.sparse_plsda"
      ]
    },
    {
      "page": "selected_vars.SparseO2pls",
      "title": "Extract selected variables from SparseO2pls S4 objects",
      "topics": [
        "selected_vars.SparseO2pls"
      ]
    },
    {
      "page": "sparse_o2pls",
      "title": "Sparse Two-way Orthogonal Partial Least Squares",
      "topics": [
        "sparse_o2pls"
      ]
    },
    {
      "page": "sparse_plsda",
      "title": "Sparse Partial Least Squares Discriminant Analysis",
      "topics": [
        "sparse_plsda"
      ]
    },
    {
      "page": "SparseO2pls-class",
      "title": "Class \"SparseO2pls\" This class represents sparse O2PLS analysis results",
      "topics": [
        "SparseO2pls-class"
      ]
    },
    {
      "page": "sparsity_info",
      "title": "Get sparsity information from sparse models",
      "topics": [
        "sparsity_info",
        "sparsity_info,SparseO2pls-method",
        "sparsity_info,sparse_plsda-method",
        "sparsity_info.SparseO2pls",
        "sparsity_info.sparse_o2pls",
        "sparsity_info.sparse_plsda"
      ]
    },
    {
      "page": "stability_selection",
      "title": "Stability Selection for Sparse Methods",
      "topics": [
        "stability_selection"
      ]
    },
    {
      "page": "summary.O2pls",
      "title": "Summary of an O2PLS object",
      "topics": [
        "summary.O2pls"
      ]
    },
    {
      "page": "summary.plsda",
      "title": "Summary of an plsda object",
      "topics": [
        "summary.plsda"
      ]
    },
    {
      "page": "summary.sparse_plsda",
      "title": "Summary of sparse PLS-DA results",
      "topics": [
        "summary.sparse_plsda"
      ]
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